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iron chelator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Antibiotic (1) Apoptosis (3) Autophagy (3) Bacterial (5) Biochemical Assay Reagents (2) DNA/RNA Synthesis (1) Ferroptosis (7) HDAC (1) HIF/HIF Prolyl-Hydroxylase (2) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (1) Monoamine Oxidase (1) NF-κB (1) Oxidative Phosphorylation (1) Parasite (1) Reactive Oxygen Species (2) α-synuclein (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Infection (5) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (6)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Ferroportin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114837

HBED

Ferroptosis Cancer

HBED is a potent iron chelator. HBED can be used to study transfusional iron overload .

HBED	Ferroptosis	Cancer
HBED is a potent iron chelator. HBED can be used to study transfusional iron overload .

HY-17359

Deferasirox 5 Publications Verification ICL 670	Bacterial Ferroptosis	Cancer
Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload .

HY-131060

CN128 hydrochloride

CN328
Others Others

CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia .

CN128 hydrochloride CN328	Others	Others
CN128 hydrochloride (CN328) is an orally active and selective **iron chelator**. CN128 is used for the research of β-thalassemia .

HY-108260

Deferitrin GT-56-252	Others	Cardiovascular Disease
Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major .

HY-124712

Divin	Bacterial	Infection
Divin, a potent chelator of iron, is a potent inhibitor of bacterial cell division with bacteriostatic effect in Gram-negative and Gram-positive bacteria. Divin disrupts the assembly of late division proteins, reduces peptidoglycan remodeling at the division site, and blocks compartmentalization of the cytoplasm .

HY-W686216

VK-28	Ferroptosis	Neurological Disease
VK-28, a brain-permeable iron chelator, inhibits both basal and Fe/ascorbate-induced mitochondrial membrane lipid peroxidation, with an IC₅₀ of 12.7 μM. VK-28 exhibits significant neuroprotective effects on ICV-6-OHDA. VK-28 can be used for the research of Parkinson’s disease and other neurodegenerative diseases .

HY-100329

CGP 65015

Ferroptosis Others

CGP 65015 is an oral iron chelator, which can mobilize iron deposits.
HY-124452

Nocardamine

Desferrioxamine E; Nocardamin
Biochemical Assay Reagents Others

Nocardamine (Deferrioxamine E)is an iron carrier/Iron chelator with antimicrobial activity .
HY-18973

Dp44mT

3 Publications Verification

Apoptosis Ferroptosis Cancer

Dp44mT is an iron chelator with selective anticancer activity.
HY-156776

HAPSBC

Others Others

HAPSBC is an S-benzyl iron chelator that mobilizes intracellular ⁵⁹Fe distribution .

CGP 65015	Ferroptosis	Others
CGP 65015 is an oral iron chelator, which can mobilize iron deposits.

Nocardamine Desferrioxamine E; Nocardamin	Biochemical Assay Reagents	Others
Nocardamine (Deferrioxamine E)is an iron carrier/Iron chelator with antimicrobial activity .

Dp44mT 3 Publications Verification	Apoptosis Ferroptosis	Cancer
Dp44mT is an **iron chelator** with selective anticancer activity.

HAPSBC	Others	Others
HAPSBC is an S-benzyl iron chelator that mobilizes intracellular ⁵⁹Fe distribution .

HY-131036

MAO-IN-M30 dihydrochloride	Monoamine Oxidase	Neurological Disease
MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC₅₀=37 nM) and MAO-B (IC₅₀=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent **iron chelator and radical scavenger**. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease . MAO-IN-M30 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-17359S

Deferasirox-d4	Isotope-Labeled Compounds Bacterial Ferroptosis	Cancer
Deferasirox-d₄ is the deuterium labeled Deferasirox. Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload[1][2][3].

HY-160078

Deferiprone O-β-D-glucuronide	Others	Metabolic Disease
Deferiprone O-β-D-glucuronide is a novel orally active **iron chelator*. Deferiprone O-β-D-glucuronide shows the capability of reducing the iron* burden in patients with β-thalassemia .

HY-17359R

Deferasirox (Standard) ICL 670 (Standard)	Bacterial Ferroptosis	Cancer
Deferasirox (Standard) is the analytical standard of Deferasirox. This product is intended for research and analytical applications. Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload .

HY-W035520

HBED dihydrochloride	Biochemical Assay Reagents	Others
HBED dihydrochloride is an orally active and hexadentate phenolic aminocarboxylate iron chelator. HBED refers to N, N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid, inducing iron excretion in primates. HBED dihydrochloride has the potential to be used as an alternative to desferriamine for iron chelation therapy .

HY-120475

PBT434 ATH434	α-synuclein	Neurological Disease
PBT434 is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 has the potential for the research of Parkinson’s disease (PD) .

HY-142072

Albomycin	Antibiotic DNA/RNA Synthesis Bacterial	Infection
Albomycin is an inhibitor of aminoacyl-tRNA synthetases with Trojan-horse effect. Albomycin is delivered by iron-chelator portion into bacterial through ferrichrome-specific transporter system. Albomycin combats against a wide range of Gram-positive and Gram-negative bacteria. Albomycin also serves as an efficient iron-scavenger of producer .

HY-120475A

PBT434 mesylate ATH434 mesylate	α-synuclein	Neurological Disease
PBT434 methanesulfonate is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 methanesulfonate can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 methanesulfonate inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 methanesulfonate prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 methanesulfonate has the potential for the research of Parkinson’s disease (PD) .

HY-N0928

Mimosine
Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity . Mimosine is a known chelator of Fe(III) . Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells . Anti-cancer, antiinflammation.

HY-B0988

Deferoxamine mesylate Maximum Cited Publications 167 Publications Verification Desferrioxamine B mesylate; DFOM	Autophagy HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species Apoptosis Akt	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Deferoxamine mesylate (Deferoxamine B mesylate) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine mesylate upregulates HIF-1α levels with good antioxidant activity. Deferoxamine mesylate also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine mesylate can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .

HY-B1625

Deferoxamine Maximum Cited Publications 167 Publications Verification Deferoxamine B; Deferriferrioxamine B; Deferrioxamine	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species Apoptosis Akt Autophagy	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .

HY-N8707

Homobutein	Parasite HDAC NF-κB	Infection Inflammation/Immunology Cancer
Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC₅₀s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation .

HY-12406

VLX600	Oxidative Phosphorylation Mitochondrial Metabolism Autophagy	Cancer
VLX600 is an iron-chelating inhibitor of oxidative phosphorylation (OXPHOS). VLX600 causes mitochondrial dysfunction and induces a strong shift to glycolysis. VLX600 displays selective cytotoxic activity against malignant cell and induces autophagy. Anticancer activity .

HBED dihydrochloride	Biochemical Assay Reagents
HBED dihydrochloride is an orally active and hexadentate phenolic aminocarboxylate iron chelator. HBED refers to N, N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid, inducing iron excretion in primates. HBED dihydrochloride has the potential to be used as an alternative to desferriamine for iron chelation therapy .

Nocardamine Desferrioxamine E; Nocardamin	Biochemical Assay Reagents
Nocardamine (Deferrioxamine E)is an iron carrier/Iron chelator with antimicrobial activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8707

Homobutein	Classification of Application Fields Source classification Plants Compositae Infection Chalcones Flavonoids Millettia pachyloba Drake Phenols Polyphenols Inflammation/Immunology Disease Research Fields Cancer	Parasite HDAC NF-κB
Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC₅₀s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation .

Cat. No.	Product Name	Chemical Structure

HY-17359S

Deferasirox-d4
Deferasirox-d₄ is the deuterium labeled Deferasirox. Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload[1][2][3].

MAO-IN-M30 dihydrochloride		Alkynes
MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC₅₀=37 nM) and MAO-B (IC₅₀=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent **iron chelator and radical scavenger**. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease . MAO-IN-M30 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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iron chelator

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
Products